Amelia Shepherd is the youngest sister of Derek Shepherd. Just like her older brother, she is a neurosurgeon, officially employed at Seaside Health and Wellness with privileges at St. Ambrose Hospital. During a long visit to Seattle, she worked at Grey Sloan Memorial Hospital, enjoying hospital privileges.

Amelia graduated at the top of her class at Harvard Medical School, completed her surgical residency at Johns Hopkins, and followed up with a neurosurgical fellowship.

She is board certified in neurosurgery and was employed as one of Dr. Geraldine Ginsberg's teaching fellows until Ginsberg fired her for discussing with a patient's husband a surgery that Ginsberg did not recommend and considered highly experimental, which was successful.

She is a world-class neurosurgeon like Derek and although talking to her brother about her situation could help her find a new position she does not want to call him because of the "lectures and the "I told you so"s and the "You screwed up again"s that she fears will follow. Amelia takes risks in surgeries and at times appears very confident in her own abilities but when problems arise she can become overwhelmed with self-doubt. Sam had to push her to finish her surgery on Addison's comatose patient after complications arose.

After she was fired by Dr. Ginsberg, Amelia worked as a neurosurgeon at the Oceanside Wellness Group. After this practice was dissolved, Amelia continued working at Seaside Health and Wellness, the successor of the Oceanside Wellness Group. While working at both practices, Amelia held hospital priviliges at St. Ambrose Hospital.

A few years later, she went to Seattle to visit her brother and sister-in-law as well as their kids. While she was there, she was given privileges at Grey Sloan Memorial Hospital and eventually started taking over her brother's practice.

She is very close to her former sister-in-law, Addison and says that she has always been a better sister to her then her real sisters. She has three sisters and one brother. She does not believe in God and does not think that people can change. She doesn't give details but she tells Sam that she has "done stuff... bad stuff". She prefers to try and help other people with their personal problems rather than deal with her own life.

Amelia shut out Addison when Addison informed her that her baby had no brain. When Amelia was in labor, she accepted Addison's help and they renewed their friendship.

Amelia has spunk and is always very outspoken and charismatic. She is that "badass" type of girl who doesn't let anything or anyone get in her way. She seems to have slight trust issues also, because of her troubled past. After overcoming her drug problems, she appears to have matured.