Isobel Katherine "Izzie" Stevens was a surgical resident at Seattle Grace Hospital. She was married to Alex Karev, but divorced him when she left after he told her he deserved better.

As a teenager, Izzie worked as a waitress and had savings for college but her mother spent most of the money on psychics. This forced Izzie to pay most of the bills with her own money. At only 16, Izzie gave birth to a daughter who she subsequently gave up for adoption. Izzie privately named her daughter Sarah but her adoptive parents named her Hannah (Izzie would later have to donate bone marrow to Hannah, who was suffering from leukemia). Because of her pregnancy, mothers made their children stay away from Izzie so she had no friends and wore cheap clothes.

When she turned 18, she left home. She paid for medical school by modeling for designer "Bethany Whisper," which led to her receiving the nickname, Dr. Model.

zzie always strives to find the best in people. She does not like it when her or close friends are messed with. Izzie is also a very confident person.